Diazotization Titration or Nitrite Titration. Diazotization is used in the analysis of aromatic compounds containing an amino group in the. View Notes – from ECH at University of Florida. Diazotization titration (Nitrite Titration) Mr. V. M. Patil Assistant Professor & PG. Quantitative estimation of Eflornithine by Nitrite (Diazotization) titration Here the amino group of Eflornithine is diazotized with sodium nitrite solution in.

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Used in the determination of the procaine. These are extremely weak and cannot be analysed using normal titrimetric methods. Aniline, aminophenol, and toluidine. What are the example drugs assayed by the diazotization titrimetry?

What is a chemical reaction? What are the advantages of diazotization titrimetry? Used in the determination of the chloropheneramine. The amine reacts with the nitrous acid to form nitrosamine, which is followed by the tautomerisation and the water molecule is lost to form the diazonium ion.

Relatively slow when compared to other methods. Start Free Trial No credit card required.


A Seminar on Potentiometric and Diazotization Titrations

Registration Forgot your password? Unknown 5 October at This resulting solution is known as the standard solution. Hence the non-aqueous titrimetric method is used. The excess of nitrous acid is determined by the addition of the starch iodide as an external indicator. They are as follows: With Safari, you learn the way you learn best. When sodium nitrite is reacted with the hydrochloric acid sodium chloride and nitrous acid are formed.

For example, the aminophenol is readily oxidized by the nitrous acid and converted to the quinones in the presence of copper sulphate solution and forms the diazo oxide compounds. Used in the determination of the sulphonamides.

Another procedure is—after maintaining the conical flask temperature, the pair of platinum electrodes is immersed. To use this website, you must agree to our Privacy Policyincluding cookie policy.

The electrode assumes a potential proportional to the logarithm of concentration ratio of the two oxidation states of the reactant or the titrant which ever is capable of properly poising the electrodes. Used in the determination of the ephedrine. Thus the electrode will act as if it were an electrode of metallic hydrogen.


The main principle involved in this method is the formation of the diazo oxide which is more stable than diazotizatuon diazo compounds. The principle involved in this method is that the primary aromatic amine present in the sample reacts with the sodium nitrite in the presence of acid such as hydrochloric acid to obtain a diazonium salt.

Diazotization Titrations

Sulphanilic acid and anthranilic acid. Volumetric or titrimetric analysis are among the most useful and accurate analytical techniques, especially. The indicator electrodes must readily come into equilibrium with one of the ions. The diazonium salts formed are not stable at elevated temperatures.

The general procedure is followed by weighing the sample and transferring it into the standard diazotizahion. Used in the determination of the P -amino benzoic acid vitamin B 4.

Lowitz first prepared the moisture-free solvents non-aqueous solvents. Stay ahead with the world’s most comprehensive technology and business learning platform.